Abstract Rad51 maintains genome integrity. whereas Rad52 causes non-canonical homologous recombination leading to gross chromosomal rearrangements (GCRs). Here we find that fission yeast Srr1/Ber1 and Skb1/PRMT5 promote GCRs at centromeres. Genetic and physical analyses show that srr1 and skb1 mutations reduce isochromosome formation mediated by centromere inverted repeats. https://www.bekindtopets.com/limited-stock-Original-U-S-Vietnam-War-Era-Operation-Igloo-White-Seismic-Sensor-Inert-Rocket-great-price/